When Simeons first began using the hormone, underdeveloped boys were given several hundred international units, delivered twice a week. A few discoveries were made by Dr. Simeons as a result of these injections. The first being that small, daily doses were just as effective as much larger ones given twice a week.
Patients began to lose their large appetite, without being on a restrictive diet.
Simeons also noticed that the boy’s body shapes began to change. Simeons believed that this was due to abnormal deposits of fat moving away from the hips and becoming available to the body to burn off. This new source of fuel could then be used in replace of food, which answered the question of why the boys were not as hungry, even when their diets became restricted.
Simeons points out that the addition of the HCG injections seemed to have no harmful effects. Patients were able to go about their normal days on only 500 calories per day and began to lose an average of a pound per day. This made it clear to Simeons that the body was transitioning to using up abnormal fat instead of the usual normal fat reserves.